GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2275426 | 1 | rs785503 | chr1:46595868 | MUTYH | chr1:45794915-45806142:- | 0.2 | 3.89 | 0.000119 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs785520 | chr1:46568836 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -6.31 | 7.8E-10 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs785520 | chr1:46568836 | MUTYH | chr1:45794915-45806142:- | 0.2 | 3.89 | 0.000117 | Body mass index |
| BLCA | cis | rs78153629 | 1 | rs78604110 | chr15:40681854 | C15orf23 | chr15:40674922-40686488:+ | 0.33 | 5.67 | 2.88E-8 | Heschl's gyrus morphology |
| BLCA | cis | rs6951245 | 1 | rs78628466 | chr7:1068453 | ZFAND2A | chr7:1192544-1199855:- | -0.36 | -4.3 | 2.15E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs786425 | 1 | rs786425 | chr12:124085502 | ATP6V0A2 | chr12:124196865-124246299:+ | -0.29 | -4.31 | 2.07E-5 | Pubertal anthropometrics |
| BLCA | cis | rs2241437 | 1 | rs78646493 | chr2:86283195 | LOC90784 | chr2:86247339-86250991:- | -0.41 | -4.21 | 3.18E-5 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| BLCA | cis | rs11088226 | 1 | rs78679088 | chr21:33910827 | TCP10L | chr21:33947152-33957845:- | -0.37 | -4.87 | 1.62E-6 | Gastritis |
| BLCA | cis | rs7868228 | 1 | rs7868228 | chr9:21667762 | LOC554202 | chr9:21454267-21559832:- | 0.26 | 3.96 | 8.99E-5 | Gut microbiome composition (winter) |
| BLCA | cis | rs7868228 | 1 | rs7868333 | chr9:21667825 | KLHL9 | chr9:21324054-21335429:- | -0.3 | -4.56 | 7.01E-6 | Gut microbiome composition (winter) |
| BLCA | cis | rs7868228 | 1 | rs7868333 | chr9:21667825 | LOC554202 | chr9:21454267-21559832:- | -0.26 | -3.92 | 0.000105 | Gut microbiome composition (winter) |
| BLCA | cis | rs11782652 | 1 | rs78724141 | chr8:82659661 | CHMP4C | chr8:82644688-82671746:+ | -0.78 | -7.44 | 6.8E-13 | Epithelial ovarian cancer;Ovarian cancer |
| BLCA | cis | rs11782652 | 1 | rs78740005 | chr8:82659306 | CHMP4C | chr8:82644688-82671746:+ | -0.78 | -7.43 | 7.2E-13 | Epithelial ovarian cancer;Ovarian cancer |
| BLCA | cis | rs2243480 | 1 | rs78803505 | chr7:65382572 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 4.38 | 1.53E-5 | Diabetic kidney disease |
| BLCA | cis | rs6951245 | 1 | rs78861357 | chr7:1095418 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.4 | 1.41E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |